dna pol

Molecular mechanism of DNA pol β in DNA repair

DNA聚合酶β在DNA修复作用中的分子机制

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Methods Twenty-six cases of nasopharyngeal carcinoma tissues and control epithelial tissues were collected to study DNA pol β gene mutation with PT-PCR, PCR-SSCP and DNA sequence analyzing technique.

方法采用RT-PCR法（逆转录DNA聚合酶链反应）、PCR SSCP（聚合酶链单链构象多态性分析）、DNA序列分析法对26例鼻咽癌组织及癌旁组织标本进行polβ基因突变研究。

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The expression of DNA pol β mRNA and protein in the A549/ TXL20 cells were significantly higher than those in A549 cells.

A549/TXL20细胞中DNA polβmRNA及蛋白的表达水平均高于A549细胞（P

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DNA polymerase B ( pol B) is the key enzyme for single base excision repair.

DNA聚合酶β（polymeraseβ，polβ）主要是单个碱基切除修复中的关键酶之一。

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The construction and identification of recombinant eukaryotic expression vector containing specific mutant DNA pol β gene derived from prostate cancer

前列腺癌特异突变DNA聚合酶β真核表达载体构建及鉴定

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Analysis reveals that DNA Polymerase beta ( pol β) in eukaryon may be of viral origin.

分析显示：真核生物DNA聚合酶beta（polβ）可能起源于病毒基因的水平转移；

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Expression of p53 Gene with DNA pol β and CMV Promoter in Salivary Adenoid Cystic Carcinoma Cells

DNA polβ启动子和CMV启动子调控的p53基因在涎腺腺样囊性癌细胞中表达的比较

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Results: Higher expression of DNA pol β mRNA, Fas mRNA and lower expression of p53 mRNA in all of brain tumors were found compared with those in normal adjacent cancer tissue ( P < 0.01).

结果：与相应瘤旁正常脑组织相比，脑胶质瘤及良性脑肿瘤组织中DNA polβ、Fas基因mRNA高表达，p53基因mRNA低表达（P均

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DNA pol β Gene Mutation in Esophageal Carcinoma RNA POLYMERASE ACTIVITY OF NUCLEI ISOLATED FROM LEAVES OF VICIA FABA

食管癌中DNA聚合酶β的突变分离的蚕豆细胞核的RNA聚合酶活力的研究

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DNA pol β Gene Mutation in Esophageal Carcinoma

食管癌中DNA聚合酶β的突变

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[ Conclusions] The A549/ TXL20 cell line shows drug resistant phenotype and may be related to overexpression of DNA pol β.

结论A549/TXL20具有多药耐药表型，耐药性产生可能与细胞内DNA polβ表达增高有关。

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Evidence also shows that DNA polymerase mu ( pol μ) is only present in mammals, and is a duplicated gene of terminal deoxynucleotidyl transferase ( TdT).

DNA聚合酶mu（polμ）基因仅存在于哺乳动物基因组中，是脱氧核苷酸末端转移酶（TdT）的重复基因；

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Methods: By using RT PCR, SSCP, analysis of DNA sequence, the mutations of DNA pol β gene in 25 cases of human esophageal cancer and the adjacent tissues from non high incidence area were tested.

方法：利用RT PCR、SSCP及DNA序列分析的方法，对河南省非食管癌高发区25例食管癌及其癌旁组织中聚合酶β基因的变异情况进行分析。

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Conclusion: The high expression of DNA pol β mRNA, Fas mRNA and low expression of p53 mRNA may be related to the carcinogenesis and development of brain tumors and their malignant degree.

结论：p53基因mRNA低表达及DNA polβ和Fas基因mRNA高表达与脑肿瘤的发生发展及恶性程度有关。

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